Data frame containing the mean off-time reduction in patients given dopamine agonists as adjunct therapy in Parkinson's disease, from 7 trials comparing four active drugs and placebo (Dias et al. 2011) .
Format
A data frame with 15 rows and 7 variables:
- studyn
numeric study ID
- trtn
numeric treatment code (placebo = 1)
- y
mean off-time reduction
- se
standard error
- n
sample size
- diff
mean difference vs. treatment in reference arm
- se_diff
standard error of mean difference, see details
Details
This dataset may be analysed using either an arm-based likelihood
using y and se, or a contrast-based likelihood using diff and
se_diff (or a combination of the two across different studies).
The contrast-based data is formatted as described in set_agd_contrast().
That is, for the chosen reference arm in each study, the mean difference
diff is set to NA, and se_diff is set to the standard error se of
the outcome on the reference arm.
References
Dias S, Welton NJ, Sutton AJ, Ades AE (2011). “NICE DSU Technical Support Document 2: A generalised linear modelling framework for pair-wise and network meta-analysis of randomised controlled trials.” National Institute for Health and Care Excellence. https://www.sheffield.ac.uk/nice-dsu.