This package contains a number of vignettes, each one walking through an example analysis. The table below gives an overview.
Many of these examples recreate analyses from the series of Technical Support Documents published by the NICE Decision Support Unit (Dias et al. 2011). The exceptions are atrial fibrillation (Cooper et al. 2009), white blood cell transfusion (Turner et al. 2012), and plaque psoriasis multilevel network meta-regression (Phillippo et al. 2020, 2022).
| Title | Outcome type | Likelihood | Link function | Notable features |
|---|---|---|---|---|
| Blocker | Counts | Binomial | logit | Pairwise MA |
| Dietary fat | Rates | Poisson | log | Analysis of log rate ratios from rate data |
| Diabetes | Counts with time at risk | Binomial | cloglog | Analysis of log hazard ratios from count data with time at risk |
| Parkinson’s | Continuous | Normal | Identity | Analysis of arm-based data, contrast-based data, and a mixture of both |
| HTA plaque psoriasis | Ordered | Multinomial (ordered) | probit | Analysis of ordered categorical outcomes |
| Statins | Counts | Binomial | logit | Meta-regression with subgroups |
| BCG vaccine | Counts | Binomial | logit | Meta-regression with a continuous covariate, predictive distributions |
| Smoking cessation | Counts | Binomial | logit | Assessing inconsistency with unrelated mean effects and node-splitting models |
| Thrombolytics | Counts | Binomial | logit | Assessing inconsistency with unrelated mean effects and node-splitting models |
| Atrial fibrillation | Counts | Binomial | logit | Meta-regression with shared class interactions |
| WBC transfusion | Counts | Binomial | logit | Informative log-Normal prior on |
| ML-NMR plaque psoriasis | Binary (IPD) and counts (AgD), and ordered categorical | Bernoulli (IPD) and two-parameter Binomial (AgD), and ordered multinomial | probit | Multilevel network meta-regression combining IPD and AgD |
| ML-NMR newly diagnosed multiple myeloma | Time-to-event with censoring | M-spline baseline hazard | log | Multilevel network meta-regression combining IPD and AgD |
References
Cooper, N. J., A. J. Sutton, D. Morris, A. E. Ades, and N. J. Welton.
2009. “Addressing Between-Study Heterogeneity and Inconsistency in
Mixed Treatment Comparisons: Application to Stroke Prevention Treatments
in Individuals with Non-Rheumatic Atrial Fibrillation.”
Statistics in Medicine 28 (14): 1861–81. https://doi.org/10.1002/sim.3594.
Dias, S., N. J. Welton, A. J. Sutton, D. M. Caldwell, G. Lu, S. Reken,
and A. E. Ades. 2011. “NICE DSU Technical Support
Documents 1-7: Evidence Synthesis for Decision Making.”
National Institute for Health and Care Excellence. https://www.sheffield.ac.uk/nice-dsu.
Phillippo, D. M., S. Dias, A. E. Ades, M. Belger, A. Brnabic, D. Saure,
Y. Schymura, and N. J. Welton. 2022. “Validating the Assumptions
of Population Adjustment: Application of Multilevel Network
Meta-Regression to a Network of Treatments for Plaque Psoriasis.”
Medical Decision Making. https://doi.org/10.1177/0272989X221117162.
Phillippo, D. M., S. Dias, A. E. Ades, M. Belger, A. Brnabic, A.
Schacht, D. Saure, Z. Kadziola, and N. J. Welton. 2020.
“Multilevel Network Meta-Regression for Population-Adjusted
Treatment Comparisons.” Journal of the Royal Statistical
Society: Series A (Statistics in Society) 183 (3): 1189–1210. https://doi.org/10.1111/rssa.12579.
Turner, R. M., J. Davey, M. J. Clarke, S. G. Thompson, and J. P. T.
Higgins. 2012. “Predicting the Extent of Heterogeneity in
Meta-Analysis, Using Empirical Data from the Cochrane Database of
Systematic Reviews.” International Journal of
Epidemiology 41 (3): 818–27. https://doi.org/10.1093/ije/dys041.