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Three data frames, ndmm_ipd, ndmm_agd, and ndmm_agd_covs containing (simulated) individual patient data (IPD) from three studies and aggregate data (AgD) from two studies on newly diagnosed multiple myeloma. The outcome of interest is progression-free survival after autologous stem cell transplant. The IPD studies in ndmm_ipd provide event/censoring times and covariate values for each individual. The AgD studies provide reconstructed event/censoring times from digitized Kaplan-Meier curves in ndmm_agd and covariate summaries in ndmm_agd_covs, obtained from published trial reports. The data are constructed to resemble those used by Leahy and Walsh (2019) .

Usage

ndmm_ipd

ndmm_agd

ndmm_agd_covs

Format

The individual patient data are contained in a data frame ndmm_ipd with 1325 rows, one per individual, and 10 variables:

study, studyf

study name

trt, trtf

treatment name

eventtime

event/censoring time

status

censoring indicator (0 = censored, 1 = event)

age

age (years)

iss_stage3

ISS stage 3 (0 = no, 1 = yes)

response_cr_vgpr

complete or very good partial response (0 = no, 1 = yes)

male

male sex (0 = no, 1 = yes)

The reconstructed Kaplan-Meier data for the aggregate studies are contained in a data frame ndmm_agd with 2819 rows and 6 variables:

study, studyf

study name

trt, trtf

treatment name

eventtime

event/censoring time

status

censoring indicator (0 = censored, 1 = event)

The covariate summaries extracted from published reportes for the aggregate studies are contained in a data frame ndmm_agd_covs with 4 rows, one per study arm, and 15 columns:

study, studyf

study name

trt, trtf

treatment name

sample_size

sample size in each arm

age_min, age_iqr_l, age_median, age_iqr_h, age_max, age_mean, age_sd

summary statistics for age (years)

iss_stage3

proportion of participants with ISS stage 3

response_cr_vgpr

proportion of participants with complete or very good partial response

male

proportion of male participants

References

Leahy J, Walsh C (2019). “Assessing the impact of a matching-adjusted indirect comparison in a Bayesian network meta-analysis.” Research Synthesis Methods, 10(4), 546–568. doi:10.1002/jrsm.1372 .